❓Question:
4. Explain the different Solubilization techniques
5. Define and understand the partitioning law, partition coefficients, and apparent partition coefficients
6. What is the shear rate when an oil is rubbed into the skin with a relative rate of motion between the fingers and the skin of about 15 cm per seconds and the film thickness is about 0.01 cm?
7. Dilatant flow is problematic during manufacturing of the dosage form as well as administering to the patients, Why? Explain in details about the reasons beyond the scope of what mentioned in your slide explore internet and use other reference books literature review to explain this statement
8. Drug X degrades by a zero-order process with a rate constant of 0.05 mg/ml.year at room temperature. If a 1 mg/ml solution is prepared and stored at room temperature:
a) What concentration will remain after 18 months?
b) What is the half-life and shelf-life of the drug?
9. The conc of a drug preparation exposed at 40 °C decreased from 1.50 mg/ml to 1.25 mg/ml in 3 months. Determine the the rxn rate assuming that the rxn follows zero order rxn. Ans 0.00667 mg/ml. A solution of drug contained 680 units/ml when prepared. It was analysed after a period of 60 days and was found to contain 400 units/ml. Assuming the decomposition is first order, at what time the drug have decomposed to one half of its original concentration?
10. The initial concentration of a drug which decomposes according to 1 order kinetics, is 94 units/ml. the specific decomposition rate K obtained from an Arrhenius is 2.09 x 10 per sec at room T (25 °C). Previous experiments have shown that below 45 units/ml, the drug is not fit for use. What expiry date should assigned to the product?
11. Based on the Q 10 what the time taken for 5% of a drug to decompose?
12. What is the remaining concentration C in mg ml of a drug (initial concentration Co = 5 mg mi-') after a time equivalent to 3 half-lives assuming that the decomposition follows first-order kinetics?
13. The initial concentration of active principle in an aqueous preparation was 6.0 x 10 gcm³. After 20 months the concentration was shown by analysis to be 3.2 x10 gcm- 3.The drug is known to be ineffective after it has decomposed to 75% of its original concentration. Assuming that decomposition follows first order kinetics, calculate the expiry date of the drug preparation.
14.The rate of decomposition of a 0.06 M glucose at 140 °C in acidic solution was found to be as follows based on this data fined K, half-life and shelf life.
Time (in hrs)
0.0 0.5 2.0
4.0
6.0
8.0
12.0
Glucose remaining (x10 mol.liter¹) 5.65 5.52 5.31 5.02 4.80 4.52 4.09
✏️Answer:
What is difference between deformation and strain
❓Question:
What is identify customer account need
✏️Answer:
What changes would you like to see for the hangover or like individual in members"
❓Question:
A company had the following balance sheet accounts and balances:
Accounts Payable
$ 24,000
Cash
$12,000
Accounts Receivable
4,000
Common Stock
?
Buildings & Equipment (net)
68,000
Retained Earnings
8,000
What is the balance of the Common Stock account?
