Many individuals with Niemann-Pick disease lack neutralizing antibodies against AAV2 or AAV9
A new study in the peer-reviewed journal Human Gene Therapy showed that more than half of individuals with Niemann-Pick disease, type C1 (NPC1) who were tested lacked neutralizing antibodies against either adeno-associated virus (AAV) 2 or AAV9.
news-medical.net/news/20250310/Many-individuals-with-Niemann-Pick-disease-lack-neutralizing-antibodies-against-AAV2-or-AAV9-A.aspx
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Insilico Medicine's AI-driven drug Rentosertib receives official generic name
Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven biotechnology company, recently announced that its breakthrough drug candidate for idiopathic pulmonary fibrosis (IPF) – Rentosertib (formerly known as ISM001-055) – has been granted an official generic name by the United States Adopted Names (USAN) Council.
news-medical.net/news/20250307/Insilico-Medicines-AI-driven-drug-Rentosertib-receives-official-generic-name.aspx
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Researchers discover brain's ability to reorganize sensory maps after loss of touch
A team of researchers from the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and Miguel Hernández University (UMH) in Elche, has discovered that the developing brain can reorganize its sensory maps when the sense of touch is affected.
news-medical.net/news/20250306/Researchers-discover-brains-ability-to-reorganize-sensory-maps-after-loss-of-touch.aspx
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How tobacco and cannabis affect male fertility and genetic integrity
A study reveals cannabis and tobacco use harm sperm quality and DNA integrity, with cannabis causing greater damage, raising concerns for reproductive health.
news-medical.net/news/20250306/How-tobacco-and-cannabis-affect-male-fertility-and-genetic-integrity.aspx
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New standards for evaluating aging biomarkers unveiled
A new paper led by Harvard researchers has zeroed in on biomarkers of aging using omic data from population-based studies.
news-medical.net/news/20240216/New-standards-for-evaluating-aging-biomarkers-unveiled.aspx
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GV1001 exerts anti-aging effects in triple transgenic Alzheimer's mice
A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, "GV1001 reduces neurodegeneration and prolongs lifespan in 3xTg-AD mouse model through anti-aging effects."
news-medical.net/news/20240215/GV1001-exerts-anti-aging-effects-in-triple-transgenic-Alzheimers-mice.aspx
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Breakthrough research unveils effects of ionizing radiation on cellular DNA
Recent release of the waste water from Japan's Fukushima nuclear disaster stirred apprehension regarding the health implications of radiation exposure.
news-medical.net/news/20240214/Breakthrough-research-unveils-effects-of-ionizing-radiation-on-cellular-DNA.aspx
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Novel assay enhances pediatric cancer treatment by identifying clinically relevant gene fusions
Identification of specific gene fusions is critical for the successful targeted treatment of pediatric cancer patients.
news-medical.net/news/20240213/Novel-assay-enhances-pediatric-cancer-treatment-by-identifying-clinically-relevant-gene-fusions.aspx
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Revvity Signals Software unveils Signals Clinical solution to accelerate critical clinical trial insights and data-driven decisions
Today, Revvity, Inc. announced that its software and informatics division, Revvity Signals, is unveiling the Signals Clinical™ solution, a software-as-a-service (SaaS), end-to-end clinical data science platform designed to centralize all clinical trial data, providing fast, actionable insights for quicker clinical decisions and accelerated market delivery of therapeutics.
news-medical.net/news/20240214/Revvity-Signals-Software-unveils-signals-clinical-solution-to-accelerate-critical-clinical-trial-insights-and-data-driven-decisions.aspx
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Researchers uncover new mechanism of action between nutrient adaptation of intestinal stem cells and aging
The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon aging.
news-medical.net/news/20240212/Researchers-uncover-new-mechanism-of-action-between-nutrient-adaptation-of-intestinal-stem-cells-and-aging.aspx
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CARB-X awards $1.8 million to Visby Medical to develop a portable rapid PCR test for gonorrhea
Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) will award up to US$1.8 million to biotechnology company, Visby Medical, to develop a portable rapid polymerase chain reaction (PCR) diagnostic to detect the presence of the pathogen that causes gonorrhea, Neisseria gonorrhoeae (NG), and its susceptibility to ciprofloxacin, a former frontline oral antibiotic that can no longer treat resistant NG.
news-medical.net/news/20240209/CARB-X-awards-2418-million-to-Visby-Medical-to-develop-a-portable-rapid-PCR-test-for-gonorrhea.aspx
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Tiny device could help improve safety, effectiveness of cell therapy for spinal cord injury patients
A tiny device built by scientists at MIT and the Singapore-MIT Alliance for Research and Technology could be used to improve the safety and effectiveness of cell therapy treatments for patients suffering from spinal cord injuries.
news-medical.net/news/20240207/Tiny-device-could-help-improve-safety-effectiveness-of-cell-therapy-for-spinal-cord-injury-patients.aspx
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New guidelines aim to improve reporting of biofield therapy trials
New guidelines for reporting clinical trials of biofield therapies are presented in the peer-reviewed Journal of Integrative and Complementary Medicine (JICM). Biofield therapies (BFTs), such as External Qigong, Healing Touch, Reiki, and Therapeutic Touch, are a related group of integrative medicine interventions in which practitioners use their hands on or above a client's body to stimulate healing and well-being.
news-medical.net/news/20240207/New-guidelines-aim-to-improve-reporting-of-biofield-therapy-trials.aspx
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Extra fingers and double hearts: Scientists decode how tiny mutations can derail development
Our genomes provide the instructions for proper growth and development. Millions of genomic switches, known as enhancers, control the location and timing of gene expression, which in turn ensures the correct proteins are made in the right cells at the right time throughout our lives.
news-medical.net/news/20240206/Extra-fingers-and-double-hearts-Scientists-decode-how-tiny-mutations-can-derail-development.aspx
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Research links kidney dysfunction to muscle weakness in myotonic dystrophy type 1
Thurman M. Wheeler, MD, of the Department of Neurology at Massachusetts General Hospital, is the senior author of a paper published in Nature Communications, "Analysis of human urinary extracellular vesicles reveals disordered renal metabolism in myotonic dystrophy type 1."
news-medical.net/news/20250308/Research-links-kidney-dysfunction-to-muscle-weakness-in-myotonic-dystrophy-type-1.aspx
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Study uncovers how transposons use telomeres for survival in bacteria
Transposons, or "jumping genes" – DNA segments that can move from one part of the genome to another – are key to bacterial evolution and the development of antibiotic resistance.
news-medical.net/news/20250307/Study-uncovers-how-transposons-use-telomeres-for-survival-in-bacteria.aspx
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Study reveals how silent X chromosome enhances female brain resilience
In a surprise, work in mice has found that the dormant X chromosome in females can reawaken late in life and turn on genes that keep the brain healthy.
news-medical.net/news/20250306/Study-reveals-how-silent-X-chromosome-enhances-female-brain-resilience.aspx
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TUM scientists develop new protein purification method using UV light
Proteins play a key role in the life sciences - from basic research and biotechnological applications to the development and manufacturing of pharmaceuticals.
news-medical.net/news/20250305/TUM-scientists-develop-new-protein-purification-method-using-UV-light.aspx
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Researchers discover protein key to toxoplasmosis pathogen multiplication
Researchers have identified a protein that evolved concurrently with the emergence of cellular compartments crucial for the multiplication of the toxoplasmosis pathogen.
news-medical.net/news/20240216/Researchers-discover-protein-key-to-toxoplasmosis-pathogen-multiplication.aspx
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Innovative treatment increases survival of people with malignant mesothelioma, trial shows
An innovative treatment significantly increases the survival of people with malignant mesothelioma, a rare but rapidly fatal type of cancer with few effective treatment options, according to results from a clinical trial led by Queen Mary University of London.
news-medical.net/news/20240215/Innovative-treatment-increases-survival-of-people-with-malignant-mesothelioma-trial-shows.aspx
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Identifying immunotherapy resistance in liver cancer linked to steatotic disease
A research team of Canadian and French scientists, led by INRS professor Maya Saleh, has been investigating immunotherapy resistance in certain patients with hepatocellular carcinoma (HCC) associated with steatotic liver disease.
news-medical.net/news/20240214/Identifying-immunotherapy-resistance-in-liver-cancer-linked-to-steatotic-disease.aspx
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Phosphoproteomic profiling reveals the complex interplay of immune cells in tumors
Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field.
news-medical.net/news/20240214/Phosphoproteomic-profiling-reveals-the-complex-interplay-of-immune-cells-in-tumors.aspx
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New AI tool revolutionizes protein function prediction
A new artificial intelligence (AI) tool that draws logical inferences about the function of unknown proteins promises to help scientists unravel the inner workings of the cell.
news-medical.net/news/20240214/New-AI-tool-revolutionizes-protein-function-prediction.aspx
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Gene editing gets a boost with new CRISPR-COPIES
CRISPR/Cas systems have undergone tremendous advancement in the past decade. These precise genome editing tools have applications ranging from transgenic crop development to gene therapy and beyond.
news-medical.net/news/20240212/Gene-editing-gets-a-boost-with-new-CRISPR-COPIES.aspx
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LSHTM researchers receive £2m funding to develop novel vaccines, diagnostics and therapeutics
Researchers from the London School of Hygiene & Tropical Medicine (LSHTM) have been awarded £2m funding through the UK Research and Innovation's (UKRI) Technology Missions Fund, to develop novel vaccines, diagnostics and therapeutics.
news-medical.net/news/20240209/LSHTM-researchers-receive-c2a32m-funding-to-develop-novel-vaccines-diagnostics-and-therapeutics.aspx
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Study evaluates large language models for autocontouring in head and neck radiotherapy
A new study evaluates an artificial intelligence (AI)-based algorithm for autocontouring prior to radiotherapy in head and neck cancer.
news-medical.net/news/20240208/Study-evaluates-large-language-models-for-autocontouring-in-head-and-neck-radiotherapy.aspx
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New treatment target found for CDKL5 deficiency disorder
Scientists at the Francis Crick Institute have found a new treatment target for CDKL5 deficiency disorder (CDD), one of the most common types of genetic epilepsy.
news-medical.net/news/20240207/New-treatment-target-found-for-CDKL5-deficiency-disorder.aspx
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New tool can help researchers to better understand the metabolism of microorganisms
Researchers from University of California San Diego, as part of a large collaboration with scientists around the world, have developed a new search tool to help researchers better understand the metabolism of microorganisms.
news-medical.net/news/20240206/New-tool-can-help-researchers-to-better-understand-the-metabolism-of-microorganisms.aspx
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Personalized medicine offers hope for millions with inflammatory bowel disease
The prevalence of inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is rapidly increasing worldwide, affecting an estimated 6.8 million people.
news-medical.net/news/20240206/Personalized-medicine-offers-hope-for-millions-with-inflammatory-bowel-disease.aspx
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